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Identifying Data
Patient is a 56-year-old female who is an office manager and is married
Source and Reliability
The patient is the historian and is trustworthy
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Chief Complaint
"I have been feeling extremely tired in the last three months, and I have been adding weight despite eating less."
History of Present Illness
The patient complains of gradual fatigue in the last three months that has been interrupting her daily functioning. She even talks of experiencing exhaustion after a complete night's rest. It does not end throughout the day and is aggravated in the afternoons. She has gained about 15 pounds despite the decrease in her caloric consumption and efforts to exercise. She mentions that she has become sensitive to cold and needs additional layers of clothing even in hot conditions. The patient reports that she has regular constipation 2-3 times a week, which is not a regular occurrence. She denies any chest pain, palpitations, shortness of breath, or dizziness. She has observed that her hair is thinning, and she feels dry skin. No relieving factors have been identified. The symptoms gradually increase and have a serious effect on her performance at work and social life.
Medications
- Lisinopril 10 mg PO (by mouth) daily, last dose taken this morning at 7:00 AM for hypertension
- Atorvastatin 20 mg PO (by mouth) daily, last dose taken this morning at 7:00 AM for hyperlipidemia
- Multivitamin PO (by mouth) daily, last dose taken this morning at 7:00 AM
- No OTC medications/ herbal supplements
Past Medical History
Allergies: No known drug, food, or environmental allergies
Childhood Illnesses: Chickenpox at age 7, denies rheumatic fever, measles, mumps, or rubella.
Adult Illnesses: Hypertension diagnosed 5 years ago, hyperlipidemia diagnosed 3 years ago
Injuries: None significant
Surgeries: Appendectomy when she was 23 years old.
Hospitalizations: Childbirth alone
Obstetric/Gynecologic: G2P2, last menstrual period 14 months ago, currently postmenopausal
Psychiatric: Denies history of mental health disorders
Health Maintenance: The last physical examination was 18 months ago
Immunizations: Up to date with Tdap, MMR (received in childhood), Hepatitis B series completed in adulthood, Polio series completed in childhood, influenza vaccine received 2 months ago, COVID-19 vaccinations current, received Pneumovax at age 50
Dental Exams: Currently getting annual checkups, most recent checkup 6 months ago with regular cleaning
Last Eye Exam: 1 year ago, wears reading glasses for presbyopia
Last Pap/GYN: 10 months since, normal outcome
Self-Breast Exam (SBE): Patient performs monthly self-breast exams, last exam 2 weeks ago with no abnormalities noted
Family History
Mother is 78 years old with a history of hypothyroidism and type 2 diabetes. Father passed away at 72 years old due to a myocardial infarction. One 53-year-old sister has Hashimoto's thyroiditis. Maternal grandmother had thyroid disease. No family history of cancer or autoimmune diseases other than thyroid disease. (See genogram below)
Personal and Social History
College graduate working as an office manager. Married for 30 years with two adult children. Likes reading and gardening, and has minimized these activities because of tiredness. Previously walked 30 minutes daily, but now struggles with energy for exercise. Diet is comprised of balanced food containing vegetables, lean protein foods, and whole grains. Denies tobacco use, alcohol use, no more than occasional wine with dinner, and denies recreational drug use. Patient is independent in all ADLs such as bathing, dressing, toileting, transferring, continence, and feeding. The patient is also independent in all iADLs, such as managing finances, shopping, meal preparation, housekeeping, transportation, and medication management, although she notes reduced energy, influencing efficiency in these areas.
Review of Systems
General: Fatigue, weight gain, cold intolerance
Eyes: Denies vision changes, eye pain, or discharge
Ears/Nose/Throat: Denies hearing loss, tinnitus, sore throat, or nasal congestion
Endocrine: Denies heat intolerance, excessive thirst, or polyuria, reports the above-mentioned symptoms.
Cardiovascular: Denies chest pain, palpitations, or orthopnea.
Respiratory: Denies cough, shortness of breath, or wheezing
Gastrointestinal: Constipation as noted, denies nausea, vomiting, diarrhea, or abdominal pain
Genitourinary: Denies dysuria, frequency, or urgency
Hematology/Lymph: Denies easy bruising, bleeding, or lymph node swelling
Integumentary: Dry skin, hair thinning
Neck: Denies neck swelling or pain
Neurological: Denies headache, dizziness, weakness, or numbness
Musculoskeletal: Reports generalized muscle aches, denies joint pain or stiffness
Psychological: Reports feeling discouraged about symptoms but denies depression or anxiety
Objective
Vital Signs
- BP: 138/86 mmHg
- Temperature: 97.2°F
- Pulse: 58 bpm
- Respirations: 14 per minute
- Height: 5'5"
- Weight: 172 lbs
- BMI: 28.6 (overweight)
Physical Examination
General: Well-groomed, alert-looking female appearing stated age, mildly fatigued
Eyes: Pupils are equal, round, and reactive to light, conjunctiva is clear, and there is mild periorbital puffiness
Ears/Nose/Throat: Tympanic membranes intact, oropharynx without erythema or exudate
Endocrine: Thyroid gland mildly enlarged, smooth, nontender, no nodules palpated
Cardiovascular: Regular rate and rhythm, bradycardic, no murmurs, rubs, or gallops, peripheral pulses 2+ bilaterally
Respiratory: Clear to auscultation bilaterally, no wheezes, rales, or rhonchi
Gastrointestinal: Abdomen soft, nontender, nondistended, bowel sounds present in all quadrants
Genitourinary: Deferred
Hematology/Lymph: No lymphadenopathy appreciated
Integumentary: Skin cool and dry, mild pallor noted
Neck: Full range of motion, no JVD
Neurological: Alert and oriented x3, cranial nerves II-XII intact, reflexes delayed, 1+ deep tendon reflexes
Musculoskeletal: Normal gait, full range of motion in all extremities
Psychological: Affect appropriate, mood appears slightly discouraged
Assessment and Plan
Differential Diagnoses
- 1. Hypothyroidism (E03.9): The patient has classic symptoms, which include fatigue, weight gain, cold intolerance, constipation, dry skin, loss of hair, and bradycardia. Hypothyroidism is found in about 5% of the general population, where the prevalence is higher among women above 50 years old (Ametepe et al., 2025). Thyroid enlargement and slow reflexes are characteristic features of the physical examination. Her family history of thyroid disease is very strong, with the mother having hypothyroidism and the sister having Hashimoto thyroiditis, which is an important risk factor. Individuals whose first-degree relative had an autoimmune thyroid disease are at a considerable risk of getting the disease (Bujnis et al., 2025). Relevant positives are fatigue, increased weight with reduction in intake, cold intolerance, constipation, bradycardia, skin parchment, delayed reflex time, and family history. Pertinent negatives are the lack of chest pains and a normal cardiovascular examination otherwise.
- 2. Depression (F32.9): Major depressive disorder might manifest itself through fatigue, change of weight, and loss of interest in activities. Nevertheless, the patient denies feelings of hopelessness, anhedonia, or suicidal thoughts. Depression alone does not explain the physical findings of bradycardia, slow reflexes, enlarged thyroid, and cold intolerance. Although she claims that she is discouraged by her symptoms, this does not seem to be a primary mood disorder but more of a reactive one.
- 3. Anemia (D64.9): Fatigue and pallor may indicate anemia. Nevertheless, the patient does not report any easy bruising, bleeding, or other hematologic symptoms. The combination of symptoms, such as cold intolerance, constipation, weight gain, and delayed reflexes, is not characteristic of isolated anemia.
- 4. Chronic Fatigue Syndrome (G93.3): Although fatigue is the most common complaint, chronic fatigue syndrome is usually accompanied by post-exertional malaise and does not explain the weight gain, cold intolerance, bradycardia, or delayed reflexes seen in this patient.
Most Likely Diagnosis: Primary Hypothyroidism (E03.9)
Pathophysiology: Primary hypothyroidism is caused by a lack of production of adequate thyroid hormones by the thyroid gland. In developed nations, the most prevalent etiology is Hashimoto's thyroiditis, which is an autoimmune disease in which the body responds by attacking thyroid tissue (Vargas-Uricoechea et al., 2025). The lowered level of thyroid hormones results in a low level of metabolism in all parts of the body, and this is the reason why the patient experiences the symptoms of decreased energy, weight gain, and intolerance to cold. Metabolism, heart activity, bowel movement, and brain reflexes are regulated by the thyroid hormones. Lipid metabolism is also impacted by hormonal deficiency, which tends to aggravate existing hyperlipidemia and increase cardiovascular risk (Rodolfi et al., 2025).
Diagnostic Testing: The first laboratory testing would be thyroid-stimulating hormone (TSH) and free thyroxine (T4). High TSH with low-free T4 is evidence of primary hypothyroidism. To identify Hashimoto's thyroiditis, Thyroid peroxidase antibodies (TPO) should be determined. A complete blood count will eliminate anemia as a diagnosis. The lipid profile must be received because hypothyroidism exacerbates hyperlipidemia (Kotak et al., 2024). Radiology testing, such as thyroid ultrasound, is not indicated at this time due to the absence of thyroid nodules observed in the physical check. Cardiac testing (ECG or echocardiography) is not indicated because the patient does not experience any chest pain or cardiac symptoms other than bradycardia, which is expected with hypothyroidism. Neurologic testing is also not indicated because the delayed reflexes are consistent with hypothyroidism.
Medications and Treatments: Levothyroxine is given as the first-line treatment of hypothyroidism as recommended by the American Thyroid Association (Eldeiry et al., 2025). The initial dose is normally 1.6 mcg/kg body weight per day, on an empty stomach. In the case of this patient, the initial dose would be about 75-100 mcg PO (by mouth) daily, to be taken lifelong as this is a chronic condition requiring continuous thyroid hormone replacement therapy. TSH is to be rechecked after 6-8 weeks with the necessary alterations of dose to maintain the TSH at a range of 0.5-2.5 mIU/L. The patients should be informed about the need to take levothyroxine regularly and avoid calcium and iron supplements within the 4-hour period of TSH measurement. The non-pharmacological approach involves routine exercise, a high-fiber diet to treat constipation, and proper hydration (Hassan et al., 2025). Monitoring of atorvastatin and lisinopril that the patient already takes should be continued, as thyroid replacement can influence the conditions.
Evaluations: Physical therapy, occupational therapy, and speech therapy evaluations are not indicated at this moment. Mental health assessment is not indicated because the symptoms of mood states in the patient seem to be a reaction to her physical condition instead of a significant psychiatric disorder.
Motivational Interviewing: I would use the motivational interviewing techniques to discuss with the patient what she knows about the hypothyroidism and concerns about the lifetime use of medication. Highlighting the fact that treatment usually leads to total elimination of symptoms in a few weeks is a way of improving adherence. Motivation during the initiation of treatment may be ensured by setting small achievable goals, like resuming daily walks as one gains more energy.
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- Ametepe, S., Yaw, B., Wormekpor, I., Kantah, B., Appiah, M., Kwadzokpui, P. K., Adejumo, E. N., Obirikorang, C., Ibrahim, A., Kwarteng, B. A., Nyarko, E. N., Osei-Yeboah, J., & Lokpo, S. Y. (2025). Hypothyroidism phenotypes, clinical characteristics, and factors associated with nodular thyroid disease in patients with hypothyroidism in Southern Ghana: A 6-year retrospective study. BMC Endocrine Disorders, 25(1), Article 1934. https://doi.org/10.1186/s12902-025-01934-z
- Bujnis, M., DeSalvo, K., Neklason, D. W., Madsen, M. J., & Jorde, L. B. (2025). Familial risk of Hashimoto’s thyroiditis in a large genealogical database. The Journal of Clinical Endocrinology & Metabolism. Advance online publication. https://doi.org/10.1210/clinem/dgaf251
- Eldeiry, L. S., Attanasio, R., Hegedüs, L., Negro, R., Papini, E., Perros, P., Gharib, H., Nagy, E. V., Žarković, M., & Garber, J. R. (2025). Use of thyroid hormones in hypothyroid and euthyroid patients in the United States: American Association of Clinical Endocrinology international collaboration with the THESIS investigators. AACE Endocrinology and Diabetes. Advance online publication. https://doi.org/10.1016/j.aed.2025.10.019
- Hassan, L. S., Alsadiq, S. F., Almarhoon, S. A., Alsubeh, H. M., Alboori, S. M., Marzooq, A., Saleh, F., & Ali, M. D. (2025). Integrated management of constipation in hypothyroidism: Evaluating pharmacological and non-pharmacological interventions. Nursing Reports, 15(10), Article 354. https://doi.org/10.3390/nursrep15100354
- Kotak, P. S., Kadam, A., Acharya, S., Kumar, S., & Varma, A. (2024). Beyond the thyroid: A narrative review of extra-thyroidal manifestations in Hashimoto’s disease. Cureus, 16, e71126. https://doi.org/10.7759/cureus.71126
- Rodolfi, S., Rurale, G., Marelli, F., Persani, L., & Campi, I. (2025). Lifestyle interventions to tackle cardiovascular risk in thyroid hormone signaling disorders. Nutrients, 17(13), 2053. https://doi.org/10.3390/nu17132053
- Vargas-Uricoechea, H., Castellanos-Pinedo, A., Urrego-Noguera, K., Pinzón-Fernández, M. V., Meza-Cabrera, I. A., & Vargas-Sierra, H. (2025). A scoping review on the prevalence of Hashimoto’s thyroiditis and the possible associated factors. Medical Sciences, 13(2), 43. https://doi.org/10.3390/medsci13020043